Rational Design of a Biomimetic Cell Penetrating Peptide Library
نویسندگان
چکیده
منابع مشابه
Rational design of a biomimetic cell penetrating peptide library.
Cell penetrating peptides have demonstrated potential to facilitate the cellular delivery of therapeutic molecules. Here we develop a set of 50 cell penetrating peptide based formulations with potential to deliver small interfering RNAs intercellularly. The transfection efficacy of siRNA containing lipid-like nanoparticles decorated with different peptides was evaluated both in vitro and in viv...
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Background: The poor permeability of the plasma and nuclear membranes to DNA plasmids are two major barriers for the development of these therapeutic molecules. Therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. Objectives: The aim of this study was to investigate the in vitro delivery of plasmid DNA encoding HPV16 E7 gene...
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Poor penetration of antitumor drugs into the extravascular tumor tissue is often a major factor limiting the efficacy of cancer treatments. Our group has recently described a strategy to enhance tumor penetration of chemotherapeutic drugs through use of iRGD peptide (CRGDK/RGPDC). This peptide comprises two sequence motifs: RGD, which binds to αvβ3/5 integrins on tumor endothelia and tumor cell...
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background: the poor permeability of the plasma and nuclear membranes to dna plasmids are two major barriers for the development of these therapeutic molecules. therefore, success in gene therapy approaches depends on the development of efficient and safe non-viral delivery systems. objectives: the aim of this study was to investigate the in vitro delivery of plasmid dna encoding hpv16 e7 gene ...
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1 Overview We describe the design principles and main algorithms for an object-oriented library for weighted nite-state transducers, which are nite automata in which each transition has an output and a weight as well as the more familiar input. The main goal of the library is to provide algorithms and representations for all the symbolic processing components (language models, dictionaries, aco...
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ژورنال
عنوان ژورنال: ACS Nano
سال: 2013
ISSN: 1936-0851,1936-086X
DOI: 10.1021/nn4027382